Italy choose Federico Chiesa, Ciro Immobile and Lorenzo Insigne in their trident attack for a Euro 2020 qualifier against Greece.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Olimpico in Rome.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Azzurri have a 100 per cent record after six games and the opportunity to mathematically secure their passage to next summer’s tournament with a victory tonight.
It would be the first time ever that Italy have qualified with three matches to spare.
Roberto Mancini must do without the likes of Alessandro Florenzi, Emerson Palmieri, Stefano Sensi, Lorenzo Pellegrini and Giorgio Chiellini.
He opts for Olimpico-based Leonardo Spinazzola, Francesco Acerbi and Immobile, with Fiorentina’s Chiesa given the nod ahead of Juventus counterpart Federico Bernardeschi.
It means there are nine different clubs represented in the starting XI this evening, as Danilo D’Ambrosio of Inter takes the right-back role rather than Giovanni Di Lorenzo.
Leonardo Bonucci makes his 92nd senior appearance for Italy, putting him alone in 10th place in the all-time charts, ahead of Alessandro Del Piero on 91.
Greece have midfielder Giorgos Masouras suspended, while Napoli defender Kostas Manolas was surprisingly not called up for international duty this month.
Sokratis Papastathopoulos, Benfica’s Andreas Samaris and forward Kostas Mitroglu also miss out.
Anything less than a victory for Greece would see them ruled out of the race for the second qualification spot, as they currently have a record of just one win, two draws and three defeats.
Italy: G Donnarumma; D’Ambrosio, Bonucci, Acerbi, Spinazzola; Barella, Jorginho, Verratti; Chiesa, Immobile, Insigne
Italy bench: Sirigu, Meret, Biraghi, Cristante, Izzo, Belotti, Grifo, Romagnoli, Zaniolo, Bernardeschi, El Shaarawy, Mancini
Greece: Paschalakis; Bakakis, Chatzidiakos, Siovas, Stafylidis; Zeca, Kourbelis, Bouchalakis; Bakasetas; Limnios, Koulouris
Greece bench: Vlachodimos, Dioudis, Lampropoulos, Siopsis, Fetfatzidis, Donis, Galanopoulos, Pavlidis, Vrousai, Mantalos, Giannoulis, Koutris
Ref: Karasev (RUS)
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Football Italia staff