Bryan Cristante makes his Roma home debut against his old club Atalanta, with Javier Pastore in a more attacking role, as Emiliano Rigoni starts for the visitors.
It kicks off at the Stadio Olimpico at 19.30 UK time (18.30 GMT).
Follow all the build-up and action as it happens while giving your views on the LIVEBLOG.
The Giallorossi started their season with a last-gasp Edin Dzeko volley giving them the 1-0 win away to Torino.
Pastore disappointed in a three-man midfield, but the exit of Kevin Strootman – who is in Marseille to join Olympique for €25m plus €3m today – means Lorenzo Pellegrini and ex-Atalanta star Cristante can step in.
That moves Il Flaco to a more advanced role as part of the trident attack with Dzeko and Cengiz Under, although Justin Kluivert is raring to get off the bench after his assist against Torino.
Diego Perotti and William Bianda are unavailable for selection.
Atalanta started their season a month ago in the Europa League preliminary rounds, already disposing of Sarajevo and Hapoel Haifa.
The first leg of their play-off with FC Kobenhavn ended goalless, despite a siege on the Danish net, and the decider is in Copenhagen on Thursday evening.
In Serie A, Papu Gomez provided two goals and an assist in a 4-0 demolition of Frosinone.
Josip Ilicic is still out for some time with a mystery illness, while ex-Roma forward Marco Tumminello is injured.
Papu is one of several players rested for this match.
Former Zenit St Petersburg winger Rigoni makes his Serie A debut from the start with Ali Adnan, Mario Pasalic and Duvan Zapata.
Roma haven’t beaten Atalanta here in Serie A since 2014, followed by two draws and as many defeats.
The Orobici won three of their last six top flight meetings, home and away, losing only once.
Giallorossi tactician Eusebio Di Francesco makes his 200th Serie A appearance on a bench.
Roma: Olsen; Florenzi, Manolas, Fazio, Kolarov; Cristante, De Rossi, Pellegrini; Cengiz Under, Dzeko, Pastore
Roma bench: Mirante, Fuzato, Karsdorp, Luca Pellegrini, Juan Jesus, Marcano, Santon, Nzonzi, Lorenzo Pellegrini, Coric, Zaniolo, Kluivert, El Shaarawy, Schick
Atalanta: Gollini; Djimsiti, Mancini, Palomino; Castagne, Pessina, Valzania, Ali Adnan; Pasalic, Duvan Zapata, Rigoni
Atalanta bench: Berisha, Rossi, Toloi, Masiello, Hateboer, Gosens, Reca, De Roon, Freuler, Cornelius, Barrow, Gomez
See the latest Serie A predictions and betting tips with Eurotips.co.uk
GO TO SOURCE
Football Italia staff